NOX1 anticorps (AA 210-260)

N° du produit ABIN6992042

L’anticorps Lapin Polyclonal anti-NOX1 a été validé pour WB, ELISA, IHC (p) et IF. Il convient pour détecter NOX1 dans des échantillons de Humain.

Aperçu rapide pour NOX1 anticorps (AA 210-260) (ABIN6992042)

Antigène: NOX1 (NADPH Oxidase 1 (NOX1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOX1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-NOX1 anticorps

Épitope: AA 210-260

Specificité: NOX1 antibody is human specific.

Purification: NOX1 antibody is affinity chromatography purified via peptide column.

Immunogène: NOX1 antibody was raised against a 15 amino acid peptide near the center of human NOX1. The immunogen is located within amino acids 210 - 260 of NOX1.

Isotype: IgG

Information d'application

Indications d'application: NOX1 antibody can be used for detection of NOX1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NOX1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NOX1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur NOX1

Antigène: NOX1 (NADPH Oxidase 1 (NOX1))

Autre désignation: NOX1

Sujet: Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress (1). NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox (1). Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv (2). NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain (1-3). NOX1 have the potential to be effective treatments for a range of ischemic diseases (4).

Poids moléculaire: Predicted: 62 kDa

Observed: 64 kDa

ID gène: 27035

NCBI Accession: NP_008983

UniProt: Q9Y5S8

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Proton Transport